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Here is the latest Big Ten Conference sports news from The Associated Press

Charges have been filed against seven Michigan State football players stemming from a melee in Michigan Stadium’s tunnel last month. That’s according to a statement from the Washtenaw County Prosecutor’s Office. Michigan State player Khary Crump faces the most serious charge — felonious assault. Charges against the six other players are misdemeanors. Five are charged with aggravated assault and one with assault and battery.

The incident occurred on Oct. 29 when multiple members of Michigan State’s football team roughed up two Michigan players. Michigan coach Jim Harbaugh had said earlier he expected the suspended Spartans to be charged.

COLUMBUS, Ohio (AP) — The stakes could hardly be higher when No. 3 Michigan visits No. 2 Ohio State. A win for 11-0 Ohio State or 11-0 means a trip to Indianapolis for the Big Ten Championship and keeping national championship hopes very much alive. Both teams enter unbeaten for the first time since 2006. It’s arguably the biggest game in the series since 2016, when Ohio State and Michigan held the same rankings as they do now.

SAN JUAN CAPISTRANO, Calif. (AP) — Keshon Gilbert scored 17 points, EJ Harkless added 16 and UNLV cruised to a 71-62 victory over Minnesota in the SoCal Challenge to remain undefeated.   Luis Rodriguez added 15 points and nine rebounds for UNLV (6-0). Jackie Johnson III had 13 points and made four 3-pointers. UNLV entered having forced 20 or more turnovers in each of its five games and pushed Minnesota to 17. Gilbert had three of the Rebels’ nine steals. Jamison Battle scored 17 points for Minnesota (4-2), which shot 37% (21 of 57) from the floor. Dawson Garcia and Braeden Carrington added 15 points apiece.

ANN ARBOR, Mich. (AP) — Jett Howard scored 19 points, making 4 of 7 3-pointers, and Michigan tuned up for a key non-conference stretch by defeating Jackson State 78-68. Terrance Williams scored 11 points and Kobe Bufkin added 10 points for the Wolverines.

Hunter Dickinson, Michigan’s leading scorer at 20.4 points per game coming in, had nine points and 12 rebounds. Michigan hosts No. 4 Virginia on Tuesday then heads to London for a game against Kentucky on Dec. 4 before opening Big Ten play.

Gabe Watson had 19 points, eight rebounds and three assists for the Tigers and Trace Young added 13 points with 10 rebounds.

BLOOMINGTON, Ind. (AP) — Race Thompson scored a season-high 20 points despite getting bloodied in the first half and led No. 11 Indiana past Little Rock 87-68. Freshman Malik Reneau scored 10 points in his starting debut for the Hoosiers who are 5-0 for the second straight season. Preseason All-American Trayce Jackson-Davis sat out with a sore back. Myron Gardner had 14 points, nine rebounds and six assists for the Trojans. D.J. Smith led Little Rock with 20 points. The Trojans were within seven midway through the second half but Indiana pulled away with 14-1 spurt.

LAHAINA, Hawaii (AP) — Justice Sueing scored 23 of his career-high 33 points in the second half to help Ohio State hold off No. 21 Texas Tech for an 80-73 win in the fifth-place game in the Maui Invitational. Sueing scored 15 points in a row for the Buckeyes in the last 10 minutes to turn back Tech each time it threatened to make a run. Ohio State shot 52% from the field, made all 18 of its free throws and never trailed after the first two minutes. Texas Tech got a career-high 21 points from Daniel Batcho and 19 from Kevin Obanor.

STATE COLLEGE, Pa. (AP) — No. 11 Penn State is fresh off three straight blowouts — Rutgers, Indiana and Maryland — in which nearly every player, no matter how young they were, contributed. And the defense especially is showing the results: 16 players have at least half a sack, while 27 have chipped in on tackles for loss. It’s a trend that should concern the Nittany Lions’ opponent this weekend: Michigan State. The Spartans are 89th in total offense nationally. Michigan State needs a win to become bowl eligible.

CANCUN, Mexico (AP) — K.D. Johnson scored 12 points, Allen Flanigan made a contested go-ahead layup with 31 seconds left and No. 13 Auburn held on to beat Northwestern 43-42 in the championship game of the Cancun Challenge. Jaylin Williams made 3 of 6 from 3-point range and finished with 11 points for the Tigers. Chase Audige led Northwestern with 10 points, three blocks and two steals. The Wildcats shot 4 of 24 in the first half and finished shooting 25% from the field and 2 of 24 from 3-point range.

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A drug company abandoned a treatment for  ‘bubble boy disease.’ After a 5-year fight, this little girl is about to get it

Later this spring, a little girl in California who essentially has no immune system will receive a lifesaving treatment for “bubble boy disease” thanks to the persistence of a dogged group of parents, a pediatrician, a veteran newsman and a few episodes of “Grey’s Anatomy.”

Five-year-old Seersha Sulack has the same rare disease portrayed in the 1976 John Travolta movie, “The Boy in the Plastic Bubble.” A germ – even a common cold – could kill her, and so she stays away from anyone outside her immediate family.

The treatment she’s been waiting for had stunning, near-perfect results in a clinical trial, but it’s been sitting on the shelf for years in the US because the pharmaceutical company that once owned the license abandoned it when it decided not to not to pursue approval from the US Food and Drug Administration.

“It’s a pretty tough situation,” said Dr. P.J. Brooks, acting director of the Division of Rare Diseases Research Innovation at the National Institute of Health’s National Center for Advancing Translational Sciences. “You have an effective therapy like (this one) and people can’t get access to it.”

Seersha is expected to get the treatment next month. She’ll become only the second child in the US in the past five years to receive it; the first child received it earlier this month.

The treatment is for a particular type of severe combined immunodeficiency called ADA-SCID that’s extremely rare – in the US, eight babies a year are born with it. Currently, 26 children in the US and Canada are on the waiting list to get the therapy, according to Dr. Donald Kohn, a UCLA scientist who has been working on the treatment for nearly 40 years.

The treatment is a type of gene therapy: Doctors will give Seersha a normal copy of the defective gene that disabled Seersha’s immune system.

Gene therapies hold great hope for all sorts of diseases, but they’re very expensive to develop, and pharmaceutical companies can’t be sure that they’ll make a profit because health insurance companies haven’t always agreed to pay the multi-million dollar price tags.

“It has not escaped our attention at FDA that there have been some clouds on the horizon in gene therapy,” Dr. Peter Marks, head of the US Food and Drug Administration’s Center for Biologics Evaluation and Research, said at a biotech conference in California in October. “We really want to try to see what we can do to move things forward.”

The gene therapy Seersha’s been waiting for was once called OTL-101, for Orchard Therapeutics Limited. Orchard launched in 2016 with OTL-101 as its “lead candidate,” but four years later, the company announced it would “reduce investment” in the therapy and prioritize treatments for more common conditions.

“A lot of us were upset and angry,” said Seersha’s mother, Shayla Sulack, noting that OTL-101 was developed with millions of dollars in state and federal government aid.

“We were always, ‘it’s going to happen, it’s going to happen,’ ” she added. Then, after Orchard decided not to pursue the therapy, “a bunch of us SCID moms were like, ‘Excuse me?’ ”

In a statement to CNN, an Orchard spokesperson wrote that “after encountering technical challenges related to the commercial-grade manufacture of this particular therapy, we made the very difficult decision to limit additional investment in [the SCID gene therapy].” The spokesperson spoke on the condition of anonymity.

A mother’s ‘oh, crap’ moment
Shayla and her husband, Stephen Sulack IV, were high school sweethearts at Tehachapi High School, about 100 miles north of Los Angeles. In 2010, when she was 18 and he was 19, they married at the Little White Wedding Chapel in Las Vegas.

Stephen was in the Army, and over the next few years, the young couple moved to various military bases. Their daughter Skylar was born in 2012 and son Stephen V in 2014.

In 2017, the family moved to Hawaii for Stephen’s new post as a Black Hawk helicopter pilot at Schofield Barracks in Oahu. Two weeks later, Seersha was born at Tripler Army Medical Center in Honolulu.

Weighing 6 pounds and 10 ounces, Seersha appeared perfectly healthy, and her parents took her on family outings, going to Dole Plantation and Waikiki Beach when she was five days old.

Strolling around the shops near the beach that day, the family went into a Tesla dealership just for fun. While sitting in a showroom car, Shayla got a phone call from a number she didn’t recognize.

It was a geneticist at Tripler. He told Shayla that a routine blood test, a prick on a newborn’s heel done in nearly every state, showed Seersha’s level of T cells – a type of white blood cell crucial to fighting off infections – was just five. Normal T cell levels for newborns are around 3,000.

This meant any infection, no matter how small, could kill Seersha. The geneticist said to bring her back to the hospital at Tripler immediately.

Shayla says her first reaction was: “Oh, crap.”

Not only had they been going everywhere with their new baby, but Seersha’s big brother and sister had been affectionately pawing all over her.

Shayla and Stephen left the Tesla dealership and made the 20-minute drive to the hospital while Shayla’s parents took the older two children home in their car.

At Tripler, doctors explained more about SCID, and a psychologist was on hand to help the Sulacks deal with the shocking news.

Only about one baby a year is born with the SCID in Hawaii, according to Sylvia Mann, genetics coordinator at the state’s department of health.

The next day, Shayla and Seersha were on a military medical transport flight to Los Angeles. Seersha was in an incubator in the front of the plane, and the other patients were kept in the back to decrease the chances they could get her sick.

An ambulance drove Shayla and Seersha to UCLA Mattel Children’s Hospital, one of 47 medical centers in the US and Canada that specialize in SCID as members of the Primary Immune Deficiency Treatment Consortium funded by the National Institutes of Health.

Once there, doctors laid out the options for saving Seersha’s life.

Options for Seersha
It turned out none of them were very good.

ADA-SCID is treated with regular injections to replace a missing enzyme that helps with immune function. They help a great deal, but they don’t give the child a full immune system, and their effectiveness can wane over time.

The UCLA doctors laid out two longer-term options. Seersha could receive a stem cell transplant, which is lifesaving and the standard treatment for SCID. Doctors would test her mother, father, brother, and sister and determine the best genetic match, and then would extract cells that specialize in forming blood cells and give them to Seersha.

Testing showed that any of her family members could donate to her, but none of them was a particularly good match. This was bad news for two reasons: One, the transplant likely wouldn’t be as effective. Two, Seersha would be more likely to suffer complications.

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Youssef Ramadan earns ACC Men’s Swimmer of the Year

After his historical season, Youssef Ramadan took the ACC Men’s Swimmer of the Year title for the 2022-23 season, the league announced Monday afternoon.

Ramadan became the first-ever national champion in program history, swimming the second-fastest 100 fly time in NCAA history at 43.15. He earned five All-American awards and two honorable mentions at NCAA’s.

Ramadan was named male MVP at ACC’s in February for the second year in a row, on top of two gold medals and two silver medals. He also took ACC Male Swimmer of the Week twice earlier in the season.

Throughout the 2022-23 season, he’s broken four individual school records and two relay records.

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Changes on tap for Americans who hunt waterfowl in Manitoba

Americans planning to hunt waterfowl this fall in Manitoba will be able to draw a seven-day license but must enter a lottery for a limited number of “foreign resident” licenses in subsequent years if they don’t book their trip through an outfitter, under new waterfowl regulations the province announced earlier this month.

“As part of the initial phase-in strategy for fall of 2023, Manitoba is ensuring that all applicants for the draw will receive a seven-day Foreign Resident Migratory Game Bird License,” Manitoba’s Ministry of Natural Resources and Northern Development said on its website. “In subsequent years the allocations for each license type will be determined based on license sales, hunter questionnaire data from all user groups and stakeholder input. The combination of the seven-day license and associated draw for freelance foreign resident hunters is intended to discourage visiting hunters from creating lasting systems of control that inhibit other hunters.”

The new regulations are a key component of the Waterfowl Hunting Modernization Project, a proposal the Manitoba government unveiled last fall before a 45-day comment period that ended Friday, Oct. 7.

American hunters will now have the opportunity to access the following Manitoba waterfowl and upland game bird licenses, the province said:

Foreign Resident Upland Game Bird License: Required to hunt upland birds and can be purchased online and is subject to the same regulatory framework as resident hunters.
Foreign Resident Migratory Game Bird License: Required to hunt migratory birds and is a seven-day license, which can be accessed either by entering a draw process or booking with a licensed outfitter.
Foreign Resident Legacy Migratory Game Bird License: A grandfathered opportunity for qualifying foreign resident landowners or lessees of Crown land.
To qualify for the special grandfathered provisions, Americans (and other foreign residents) must have owned property in Manitoba before Sept. 1, 2022, and still own that property; be a shareholder of a corporation owning registered property in Manitoba; or be a crown land lessee. Eligible land interest holders must also have hunted waterfowl in Manitoba during the previous five years between 2018 and 2022 to qualify for the legacy license.

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